Microdosimetric calculations of the direct DNA damage induced by low energy electrons using the Geant4-DNA Monte Carlo code
نویسندگان
چکیده
منابع مشابه
Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit
Background: The total yields of direct Single-Strand Breaks (SSBs) and Double-Strand Breaks (DSBs) in proton energies varying from 0.1 to 40 MeV were calculated. While other studies in this field have not used protons with energy less than 0.5 MeV, our results show interesting and complicated behavior of these protons. Materials and Methods: The simulation has been done using the Geant4-DNA too...
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Today, targeted radiation therapy (TRT) methods for cancer treatment, besides the goal of completely destroying the target tumor, attempts to prevent nearby healthy cells from exposure to ionizing radiation as far as possible. Hence, short-range charged particles, such as low-energy electrons that are suited to achieving these two goals together, play an important role in TRT and so, adoption o...
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Radiotherapy using various beams is one of the methods for treating cancer, Hadrons used to treat cancers that are near critical organs. The most important part of the cell that is damage by ionizing radiation is DNA. In this study, damages induced in the genetic material of living cells (DNA) defined by the atomic model from the protein data bank (PDB) have been studied by radiati...
متن کاملMechanism and site of attack for direct damage to DNA by low-energy electrons.
We report results on the desorption of OH- induced by 0-19 eV electrons incident on self-assembled monolayer films made of single and double DNA strands of different orientations with respect to a gold substrate. Such measurements make it possible to deduce the mechanism and site of OH- formation within a biomolecule as complex as DNA. This type of damage is attributed to dissociative electron ...
متن کاملMicrodosimetry study of a multicellular model with mono-energetic electrons using Geant4-DNA simulation toolkit
Introduction: The goal of any type of radiation therapy in the treatment of tumors, in addition to destroying cancer cells, is to minimizing radiation to nearby healthy cells and thus reducing side damages. For this purpose, targeted radiation therapy (TRT) is more effective in treating of single cells or small cluster of cells. The main factor in the success of this method is...
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ژورنال
عنوان ژورنال: Physics in Medicine & Biology
سال: 2020
ISSN: 1361-6560
DOI: 10.1088/1361-6560/ab6b47